% IPD in adults 19–64 years caused byserotypes included in PNEUMOVAX 23IPD cases (%)100608040200~72%% IPD in adults ≥65 years caused byserotypes included in PNEUMOVAX 23IPD cases (%)100608040200~57%SerotypeEstimated contribution to IPD (%)a14%10%6%12%8%4%2%0%383435F417F7F10A7C3119F2015Bb6C11A23B16F819A33F15A12F35B9N23A22F31.01.11.31.41.51.71.91.92.03.23.33.3b3.43.43.73.84.24.24.44.54.74.94.94.911.212.3Serotype35B19A23A12F833F15A22F9N315Bb7F7C3411A2017F10A383135F19F423B6C16FTop 10 serotypes causing IPD in US adults aged ≥65 years, 2018IPD cases per 100,0004.02.03.01.00.0322F11A9N33F19A35B23A15A6C310A19A7F15B33F29V19F6B1423F411A20817F19N18C512F22F4447F4842464347A41A41F453435C3935A37384035F33E33D3625A28F32F273133B33C24F28A32A25F24B2933A18C19C18F2120A24A19B20B22A12A12B15C17F15F16F18B1315B17A16A18A10C11D11B11F10B11C10F9L11E6F7B6H7F6E7A6G6D7C2133F35B23A22F23F19F19A23B1415A12F9V10A9N11A9A846C6A36B5

Impact of Serotypes on Invasive Pneumococcal Disease

Polysaccharide Capsule:
Primary Virulence Factor1–5

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IgA=immunoglobulin A; Ply=pneumolysin.

Serotypes Responsible for Majority of
Pneumococcal Disease1–8

4447F4842464347A41A41F453435C3935A37384035F33E33D3625A28F32F273133B33C24F28A32A25F24B2933A18C19C18F2120A24A19B20B22A12A12B15C17F15F16F18B1315B17A16A18A10C11D11B11F10B11C10F9L11E6F7B6H7F6E7A6G6D7C2133F35B23A22F23F19F19A23B1415A12F9V10A9N11A9A846C6A36B5

There are approximately 100 known pneumococcal serotypes.2 However, most pneumococcal disease worldwide is caused
by certain serotypes (highlighted here).3–7

Study designs vary; data cannot be used to form conclusions about the global burden of disease.

Serotypes Responsible for
Burden of Pneumococcal Disease1–8